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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC6 All Species: 44.85
Human Site: S201 Identified Species: 75.9
UniProt: Q99741 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99741 NP_001245.1 560 62720 S201 K A G S L Y L S G A P G T G K
Chimpanzee Pan troglodytes XP_001170406 560 62717 S201 K A G S L Y L S G A P G T G K
Rhesus Macaque Macaca mulatta XP_001096756 559 62520 S201 K A G S L Y L S G A P G T G K
Dog Lupus familis XP_537648 559 62507 S200 K A G S L Y L S G A P G T G K
Cat Felis silvestris
Mouse Mus musculus O89033 562 62595 S203 K A G S L Y L S G A P G T G K
Rat Rattus norvegicus NP_001101768 561 62295 S202 K A G S L Y L S G A P G T G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519126 361 39672 S40 I P Q S L P C S P P K Q S K K
Chicken Gallus gallus
Frog Xenopus laevis NP_001081844 554 60731 S195 K A G S L Y I S G A P G T G K
Zebra Danio Brachydanio rerio NP_001120805 561 61262 S217 K P S S L Y I S G A P G T G K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648247 662 75116 S296 T S G S L Y V S G Q P G T G K
Honey Bee Apis mellifera XP_625142 549 62089 S194 T S G S L Y V S G P P G T G K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999666 582 64455 S194 K P G S L Y I S G A P G T G K
Poplar Tree Populus trichocarpa XP_002299817 498 55546 P177 A K E A G F Q P P D V L T M N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P09119 513 58018 D191 K I F D S F Q D L N G P T L Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96 89.1 N.A. 79.5 80 N.A. 45.3 N.A. 63.7 49 N.A. 33.9 36 N.A. 40
Protein Similarity: 100 100 97.5 93.5 N.A. 87.3 88.9 N.A. 52.8 N.A. 77.5 67.3 N.A. 52.1 57.3 N.A. 58.5
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 26.6 N.A. 93.3 80 N.A. 73.3 73.3 N.A. 86.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 33.3 N.A. 100 86.6 N.A. 86.6 86.6 N.A. 93.3
Percent
Protein Identity: 25.8 N.A. N.A. N.A. 20.1 N.A.
Protein Similarity: 46.4 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 6.6 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 20 N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 50 0 8 0 0 0 0 0 65 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 8 0 8 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 8 0 0 15 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 72 0 8 0 0 0 79 0 8 79 0 79 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 0 0 0 0 22 0 0 0 0 0 0 0 0 % I
% Lys: 72 8 0 0 0 0 0 0 0 0 8 0 0 8 86 % K
% Leu: 0 0 0 0 86 0 43 0 8 0 0 8 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % N
% Pro: 0 22 0 0 0 8 0 8 15 15 79 8 0 0 0 % P
% Gln: 0 0 8 0 0 0 15 0 0 8 0 8 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 15 8 86 8 0 0 86 0 0 0 0 8 0 0 % S
% Thr: 15 0 0 0 0 0 0 0 0 0 0 0 93 0 0 % T
% Val: 0 0 0 0 0 0 15 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 79 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _